Here are 10 observations from the game:
1. Alex Smith's toughness and leadership was on full display
There was a lot of talk throughout the week about the Eagles' standout defensive front, led by two-time Pro Bowl defensive tackle Fletcher Cox.
The talk was there for good reason, and they once again showed why they're considered one of the best in the league Sunday afternoon—sacking Chiefs' quarterback Alex Smith four times and shutting down the Chiefs' running game for much of the early part of the game.
Despite being consistently harassed, Smith finished 21 of 28 for 251 yards and a touchdown through the air, but it was his five-yard scramble on third-and-4 late in the game deep in Eagles' territory that was the difference.
Smith sacrificed his body and made a play in a situation in which the game could have gone either way.
It was one of the key momentum-building plays of the game for the Chiefs, who would find the end zone just two plays later.
2. Travis Kelce showed he can fly
**After Smith's scramble, the next two plays inside the red zone went to tight end Travis Kelce, who would lead all players with eight receptions for 103 yards on the day.
On second-and-5 from the Eagles' 15-yard line, Kelce took a shovel pass across the middle from Smith and turned it up the field. He then gloriously leapt in the air from the five-yard line over a few Eagles' defensive players and landed in the end zone.
It was everything.
3. Rookie running back Kareem Hunt did it again
After his fantastic NFL debut last week over the Patriots, Hunt was challenged to show it wasn't a fluke—that his performance wasn't a byproduct of Andy Reid's months of preparation for the Patriots.
That question was answered Sunday, when Hunt finished with 13 carries for 81 yards and two touchdowns, adding three catches for 28 yards as well.
The first touchdown came after Hunt had carried the ball seven times for just nine yards, and thanks to key blocks from left tackle Eric Fisher and left guard Laurent Duvernay-Tardif, Hunt took his eighth handoff off the left side and raced 53 yards for the touchdown—showing off the speed that had him clocked as the fastest player in the NFL last week.
Hunt's second touchdown showed another side.
First, there was speed, and then there was power.
With a little more than two minutes remaining in the game and with the Chiefs holding a seven-point lead at 20-13, Hunt wrestled his way through the Eagles' defense for a two-yard score, which ultimately proved to be the difference.
4. Justin Houston takes over the fourth quarter
After a two-sack performance last week against the Patriots that he said wasn't good enough, Justin Houston was out to prove something again this week against the Eagles.
And late in the game, it was once again Houston that sealed the deal.
Just three plays after Eagles' quarterback Carson Wentz made a nice move in the open field on him to pick up a first down on a 13-yard scramble, Houston was able to get his hands on a screen pass that deflected up into the air and into the hands of second-year defensive lineman Chris Jones, who had a nice day himself.
The Jones' interception, which is the first for the Chiefs this year, led to Kelce's touchdown, which gave the Chiefs the 20-13 lead in the fourth quarter.
On the ensuing drive after the Chiefs' touchdown, Houston sacked Wentz on first down to stall the drive before it even started. The Eagles went three-and-out following the Chiefs' go-ahead touchdown with less than six minutes remaining in the game.
Wentz, who went just 1-of-7 for minus-3 yards against pressure, finished the game 25 of 46 for 333 yards with two touchdowns and an interception. He was sacked six times.
5. Chris Jones has the game of his life
**There's no denying that Jones had a fantastic rookie season, finishing as a Pro Football Focus darling and routinely causing havoc up front as he worked his way into the defensive rotation.
But he never had a day like he did on Sunday.
Jones' marquee moment last year was probably his sack of Panthers' quarterback Cam Newton that led to an improbable victory that day, or it was his affinity for getting the crowd going before a few plays in the playoff game over the Steelers.
But it's what he did after the snap Sunday that people will remember.
Jones finished with three sacks, two forced fumbles and an interception—displaying an inability to be contained in a game in which he needed to step up, as did everyone, with All-Pro safety Eric Berry being out.
Jones, who had just two sacks during a great rookie season, has already surpassed that in just two games this year.
6. Smith's late 35-yard strike to Chris Conley was indicative of much more
With a little more than four minutes left in the game and with the Chiefs already holding a seven-point lead at 20-13, the idea was the Chiefs could run the clock a little bit and perhaps get into field goal range for Cairo Santos.
The Chiefs had the ball at midfield after a Smith run to the outside on first down went for no gain.
As the Chiefs faced a second-and-10 at their own 44-yard line, they had other plans than to accept just running some time off the clock and basically being conservative.
They went for it, and it paid off.
Smith and receiver Chris Conley hooked up for a deep 35-yard strike down the right sideline, which was an option play based on the coverage, and Conley disguised it perfectly for Smith, who hit him in stride for the chunk play that set up the Chiefs' game-sealing touchdown with Hunt.
It was a play that meant much more than just 35 yards. It showed the Chiefs' offense will attack to finish.
7. Center Mitch Morse left early with injury
Late in the second half, Morse left the game with what Reid called a "foot sprain" after the game.
Morse was replaced by Zach Fulton, who had a key block on the Kelce 15-yard touchdown reception on the shovel pass, which was the first play Fulton was on the field.
8. Long-snapper James Winchester forced a fumble late in first half
With all the second-half fireworks and standout performances late in the game, the play made by long-snapper James Winchester late in the first half shouldn't go unnoticed.
While covering a punt deep in Eagles' territory after the two-minute warning, Winchester forced the ball loose from returner Darren Sproles, and it was recovered by Anthony Sherman.
A few plays later, Santos hit a 39-yard field goal and the Chiefs were able to take a 6-3 into halftime.
9. Daniel Sorensen channeled his inner-Travis Kelce
One of the guys who was going to be counted upon after the season-ending loss of veteran All-Pro safety Eric Berry is Daniel Sorensen, who finished Sunday's game tied for the team-lead with six tackles.
Sorensen also led the Chiefs with three quarterback hits, and one of them is a play nobody will soon forget.
Blitzing off the right side of the offensive line, Sorensen leapt up over the Eagles' blocker and was able to get a hand on Wentz, who quickly threw an incomplete pass.
It was eerily similar to the way in which Kelce leapt up over the defensive players for the touchdown.
Photos from the Chiefs Week 2 matchup against the Eagles
10. The Chiefs' followed up the offensive explosion in Week 1 nicely
The Chiefs had the tall-task this week of trying to follow up an impressive 537-yard offensive output against the Patriots in Week 1. That performance put them on pace to shatter the all-time NFL record for total yards in a season.
All signs were there for a let-down, but despite a slow start, the Chiefs still put up big numbers against the Eagles.
Overall, the Chiefs picked up 344 yards on 51 plays, which is good for an average of 6.7 yards per play. While it's not the 8.3 they had against the Patriots, it's still a phenomenal number.
In the two games, Smith is a combined 49 of 63 (78 percent) for 619 yards with five touchdowns and no interceptions. He's on fire.
Whether it's Smith through the air, Hunt on the ground, or Houston and Jones getting after the opposing quarterback, the Chiefs are finishing on both sides of the ball. It's a great combination.