Besides losing the game, the Chiefs lost linebacker Derrick Johnson and defensive end Mike DeVito, both to ruptured Achilles injuries.
Coach Reid spoke about Johnson's injury after the game.
"He's a great player but I expect other guys to step up and do the job," Reid said.
In their absence, the Chiefs weren't able to stop the Titans, who managed 405 yards of total offense.
Dontari Poe spoke about losing Johnson after the game.
"It's hard to see him go down," Poe said. "I know how hard he works at it. I know the amount of work he puts in so it's really tough on him right now. So we just go to keep motivating him to get better."
Cornerback Sean Smith echoed Poe's sentiment, but said the next guy has to be ready.
"The next guy has to step in and not necessarily be DJ but just do a job," Smith said. "Go out there and be himself, and let the rest of us rally around him."
After Johnson's injury, the Titans scored on five of their next six possessions.
The Chiefs were led on offense by receiver Donnie Avery, who had seven receptions for 84 yards. Tight ends Anthony Fasano and Travis Kelce combined for six receptions for 78 yards.
But for the most part, offensively, the Chiefs weren't able to get things going most of the day.
Running back Jamaal Charles had just 11 touches in the game, and Reid said after the game that the Titans did a good job game planning against the Chiefs star player.
"They took a few things away that we had designed for him," Reid said.
Photos from the Chiefs week one game against the Titans.
Charles finished with seven carries for 21 yards, also adding four receptions for 15 yards.
Finishing just 1 of 12 on third down, the Chiefs managed just 245 yards of total offense.
"I take responsibility for the offensive side," Reid said. "That was a terrible game that I called. I didn't give the guys an opportunity—didn't put them in a position to make plays.
"We put the defense in a big-time bind a number of times."
Chiefs quarterback Alex Smith uncharacteristically threw three interceptions on the day, finishing 19 of 35 for 202 yards and one touchdown.
Those three turnovers, plus the Titans offense converting 7 of 16 chances on third down, and it was just too much for the Chiefs to overcome.
The Chiefs had the ball for just over eight minutes total in the second half.
They have a week to prepare for the Denver Broncos.
Linebacker Josh Mauga summed up the attitude in the locker room after the game.
"It's a long season. Anything can happen if we bounce back next week."
|Team/Quarter||Time||Scoring play||Drive (plays, yards, time)||Score|
|Chiefs 2||13:35||C.Santos 35 yd. Field Goa||(8-64, 4:18)||0 3|
|Titans 2||3:31||D.Walker 5 yd. pass from J.Locker||(11-62, 6:30)||7 3|
|Titans 2||0:03||R.Succop 36 yd. Field Goal||(4-24, 0:25)||10 3|
|Titans 3||10:26||K.Wright 6 yd. pass from J.Locker||(9-80, 4:34)||17 3|
|Titans 3||2:46||R.Succop 31 yd. Field Goal||(9-45, 3:45)||20 3|
|Titans 4||12:39||R.Succop 46 yd. Field Goal||(7-16, 3:47)||23 3|
|Chiefs 4||10:09||A.Fasano 5 yd. pass from A.Smith||(10-83, 2:30)||23 10|
|Titans 4||4:50||R.Succop 47 yd. Field Goal||(10-51, 5:19)||26 10|
BERRY LEADS TEAM IN TACKLES:S Eric Berry led the Chiefs defense with 15 tackles (14 solo), a new single-game career-high for the fifth-year player. His previous single-game high was 12 tackles, set in two games, both coming in his rookie year in 2010.
FULTON MAKES FIRST CAREER START AS ROOKIE:Rookie G Zach Fulton started at left guard in today's contest, the only rookie to start in the club's opening game of 2014. Fulton becomes the first sixth- or seventh-round Chiefs draft pick to start in the club's Week 1 contest in three decades. The last sixth-round draft pick to start was CB Steve Taylor in 1976. In 1984, Chiefs CB Kevin Ross started in Week 1 as a rookie seventh-round draft pick.
SHERMAN MAKES IMPACT ON SPECIAL TEAMS:FB Anthony Sherman forced a RB Leon Washington fumble on a kickoff return, which was eventually recovered by the Titans.
COLQUITT PUTS PUNTS INSIDE 20:P Dustin Colquitt booted five punts for 213 yards (42.6 gross, 43.0 net) with two inside the 20-yard line. He has landed 287 career punts inside the 20-yard line, the most in Chiefs history. His 287 punts inside the 20 rank 12th in NFL history.