Chiefs wide receiver Donnie Avery had surgery Friday for a sports hernia and has been ruled out for Sunday's game at San Francisco, though he is expected back later this season.
The Chiefs have their bye week after playing the 49ers.
Pro Bowl safety Eric Berry also will miss his third straight game with a high ankle sprain, though wide receiver De'Anthony Thomas is expected to make his NFL debut after dealing with a hamstring injury that has kept him out since training camp.
The Chiefs also get right tackle Donald Stephenson back from a four-game suspension for violating the NFL's performance-enhancing drug policy. Stephenson is expected to serve as the backup to Ryan Harris, who has started in his absence.
Back at practice on Wednesday at the University of Kansas Training Facility, Chiefs working on preparation for San Francisco