The Kansas City Chiefs lost a tough one on Sunday night, falling to the Indianapolis Colts to drop their first game of the season.
Here are six interesting notes from the game.
1. Despite the loss, Patrick Mahomes continued to re-write the record books.
Mahomes now has a league-leading 1,831 passing yards this season all without throwing a single interception, which broke Peyton Manning's NFL record for the most passing yards to begin a season without tossing a pick.
The 24-year-old Mahomes also reached yet another impressive milestone in just his second full season as a professional, courtesy of NFL Research.
Additionally, Mahomes threw for 300+ yards for a fifth-straight game to begin the year, joining Manning ('09, '13), Kurt Warner ('00) and Steve Young ('98) as the only quarterbacks in NFL history to do so.
2. Tyrann Mathieu tallied his first interception as a member of the Chiefs.
Mathieu picked off Colts' quarterback Jacoby Brissett deep inside Kansas City territory in the second quarter to thwart a scoring threat and notch his first interception in the red and gold.
As a group, Kansas City yielded just one touchdown in five trips to the red zone for the Colts, who were scoring on 71.4 percent of their red zone drives coming in to the game. The Chiefs also held Indianapolis – which was converting 49 percent of third down opportunities prior to Sunday - to just 5-of-14 on third down.
3. Byron Pringle put together the best game of his young career.
Pringle was given an opportunity when fellow wide receiver Sammy Watkins came out of the game on Sunday, and the Kansas State product certainly made the most of it. Pringle hauled in a team-leading six catches for 103 yards and the first touchdown of his career in the game.
The second-year receiver is the fourth member of the Chiefs to tally a 100-yard receiving game already this season.
4. The Chiefs' unprecedented streak of scoring at least 26 points came to an end.
Kansas City had scored 26 or more points in an NFL-record 22-straight games (including the postseason) headed into Sunday night's game before the streak came to an end against the Colts.
The Chiefs averaged 34.6 points-per-game during the streak.
5. The Colts made plays when they needed to with the running game.
Indianapolis tailback Marlon Mack carried the ball 29 times on Sunday night, which matched the most rushing attempts by any player in the NFL this season. He made the most of those carries with 132 yards on the ground, ultimately leading the Colts to a victory.
6. Penalties hurt the Chiefs on Sunday.
The Chiefs committed a season-high 11 penalties in the game for 125 yards. Here's more from Head Coach Andy Reid's post-game presser:
"Penalties are really what hurt us today. You get things going and then all of a sudden, you're going backwards. In this league, it's hard [when you do that] against a good football team."