The Kansas City Chiefs will aim to get back on track this weekend in a prime-time matchup against the Detroit Lions at GEHA Field at Arrowhead Stadium.

Here are five things to keep in mind heading into game day.

1. Here's a look at the final injury report for both teams.

The primary injury status of note for Kansas City heading into Friday was that of wide receiver Xavier Worthy (shoulder/ankle), who missed Thursday's practice. Worthy was back on Friday, however, and "moved around pretty good" according to Head Coach Andy Reid.

Worthy was listed as a full participant in Friday's practice and has no injury designation heading into the game, indicating that he's good to go.

In some additional good news, it appears that defensive tackle Omarr Norman-Lott (shoulder) and cornerback Kristian Fulton (ankle) are set to return this week after missing time.

As for the Lions, they have a handful of significant injuries worth monitoring. Starting safeties Kerby Joseph (knee) and Brian Branch (ankle) are each listed as "Questionable" for Sunday's game, and according to Head Coach Dan Campbell, both players will be game-time decisions. The availability of either player is further magnified by the fact that Detroit will be without starting cornerbacks Terrion Arnold (shoulder) and D.J. Reed (hamstring), not to mention the availability of cornerback Avonte Maddox (hamstring) is in question.

On offense, starting left tackle Taylor Decker (shoulder), who missed last week's game due to injury, is listed as "Questionable" for Sunday night. Additionally, the player who filled in for Decker last week, Giovanni Manu, is listed as "Questionable" as well due to a knee injury.

2. The Lions' high-powered offense begins with their running game.

Detroit leads the NFL in scoring through Week 5, averaging 34.8 points-per-game, and that's despite tallying just 13 points against the Packers in the season-opener. The Lions have topped at least 34 points in all four of their matchups since then, and at the core of Detroit's success offensively has been the dynamic duo of tailbacks David Montgomery and Jahmyr Gibbs, who have combined for 635 rushing yards this year.

The Lions rank second in the NFL in rushing attempts this year with 152, and those carries have been split right down the middle between Gibbs (70 carries) and Montgomery (61 carries). As a result, Detroit is the only team to feature multiple 300-yard rushers so far this year, and when the running game is working well, it sets up a ruthlessly efficient passing attack that makes the Lions very difficult to slow down.

Quarterback Jared Goff leads the NFL in completion percentage at 75.2% while distributing the football to playmakers like wide receiver Amon-Ra St. Brown, tight end Sam LaPorta and wide receiver Jameson Williams, leading an offense that racks up 365 yards-per-game on average. St. Brown, in particular, leads the NFL in touchdown grabs (6) and ranks second in receiving first downs (25).

It all begins with their running game though, and while difficult to stop, opponents have found success against it at times this season. Notably, the Packers held Gibbs and Montgomery to a combined 44 rushing yards in Week 1, ultimately leading to an off-balance performance by Detroit that held the Lions without a touchdown until the final minute of the game.

The Chiefs have been largely successful against opposing running backs this season, too, holding the likes of Saquon Barkley (88 yards), Travis Etienne (49 yards), Omarion Hampton (48 yards) and Derrick Henry (42 yards) to manageable totals.

The first step to a victory on Sunday night will be doing the same against Gibbs and Montgomery.

3. Detroit ranks second in the NFL in sacks this season.

The Lions' 16 sacks rank second in the league so far this season, and the man leading the way has been edge-rusher Aidan Hutchinson, whose 31 pressures are tied for the most in the NFL.

Hutchinson, the No. 1 overall pick in the 2022 NFL Draft, is the definition of a game-wrecker. He has five sacks through just five games, and at only 25 years old, he's already one of the league's best pass-rushers.

Despite that pass-rush, however, Detroit ranks 17th in scoring defense so far this season at 22.4 points allowed-per-game. The Lions have also allowed 18 plays of 20+ yards (10th-most in the league) and a touchdown rate of 66.7% in the red zone (seventh-highest in the NFL).

The Lions are also missing some significant contributors in defensive backs Terrion Arnold and D.J. Reed, but none of that matters if the Chiefs can't protect quarterback Patrick Mahomes from Detroit's relentless pass-rush. Kansas City held up well in pass-protection last week, and they'll need to do the same on Sunday night.

4. Detroit is 19-0 when it wins the turnover margin since the beginning of the 2023 season.

The Lions play excellent complimentary football, and it's illustrated through a ridiculous 19-0 record when they win the turnover margin since the beginning of the 2023 season. Only Buffalo has more such wins in that span, and among teams with an undefeated record in those situations during that time, Detroit has nine more wins than the next closest team.

Conversely, when the Lions have lost the turnover margin in that span, they're just 5-6.

It's basic football, but especially against a team like this, winning the turnover margin will be critical on Sunday night.

5. The Chiefs will need to avoid the uncharacteristic mistakes that plagued them last week.

Kansas City looked excellent at times last week, particularly on offense, where the Chiefs piled up nearly 500 yards and went 4-for-5 in the red zone. Unfortunately, a handful of key mistakes allowed the Jaguars to hang around and, ultimately, win the game.

The most obvious of those miscues was Jacksonville's 99-yard pick-six that provided the Jaguars with their first lead of the game. The play, which represented a 14-point swing, turned a Chiefs' possession that drove all the way to Jacksonville's 3-yard line into seven points for the Jaguars, and in many ways, the play turned out to be the difference in the game.

The other primary issue last week was that Kansas City piled up its most penalties in a game (13) since the 2018 season. Several of those penalties took place at critical junctures in the game and led to points for Jacksonville, too.

Both of those factors – the pick-six and the penalties – were uncharacteristic miscues that overshadowed an otherwise strong performance against a solid opponent, and while it doesn't mean much in a loss, the positive aspects of Monday night's game certainly bode well for the future.

It's just a matter of eliminating the mistakes – something Kansas City has managed to do better than any other team over the years – and there's no better time to flip the script than this Sunday night against Detroit.